Precocious and premature puberty associated with treatment of acute lymphoblastic leukaemia.

Whether all patients with Central precocious puberty should be treated?

Extended Abstract   Precocious puberty is the appearance of secondary sexual characteristics before 8 years old in girls and 9 years old in boys. Precocious puberty is divided into 3 groups of central, peripheral and normal variants. Central precocious puberty is accompanied by activation of hypothalamic-pituitary-gonadal axis which causes increase in secretion of GnRH, and in turn increase i...

انواع بلوغ زودرس وعلل زمینه ای آن و لزوم درمان بیمارستان امام، 79-1372

Background: This study was performed in order to detect the frequency of different types of precocious puberty, predisposing factors and to show which group of patients need to treatment. Materials and Methods: In this study, 74 patients who referred to pediatric endocrine clinic of Imam Khomeini Hospital and private office from 1993-2000 were assessed. A complete history was taken and physical...

Impaired pubertal growth in acute lymphoblastic leukaemia.

The growth of 182 patients who were long term survivors of childhood acute lymphoblastic leukaemia was retrospectively analysed. All remained in first remission and were treated with either 1800 or 2400 cGy of cranial irradiation. None had been treated with either testicular or spinal irradiation. Ninety three (51 boys, 42 girls) were treated with 2400 cGy and 89 (42 boys, 47 girls) were treate...

Investigation of TEL/AML1 and BCR/ABL Fusion Genes in Patients Affected by Acute Lymphoblastic Leukaemia Using Interphase in situ Hybridization

Serum vitamin D levels in girls with central precocious puberty

Precocious puberty can cause several adverse effects on final growth and social behavior in girls. Recently studies showed that low serum vitamin D levels might be associated with precocious puberty. The aim of  this research was to investigate the association between serum vitamin D levels and central precocious puberty in girls. Girls with central precocious puberty under the age of 8 we...